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Nausea and vomiting are common experiences in pregnancy, affecting 70–80% of all pregnant women. Although most women with nausea and vomiting of pregnancy (NVP) have symptoms limited to the first trimester, a small percentage of women have a prolonged course with symptoms extending until delivery. Women with severe nausea and vomiting during pregnancy may have hyperemesis gravidarum (HG), an entity distinct from NVP, which if left untreated may lead to significant maternal and fetal morbidity.
Various metabolic and neuromuscular factors have been implicated in the pathogenesis of NVP and HG; however, their exact cause is unknown. Consequently, treatment of NVP and HG can be difficult as neither the optimal targets for treatment nor the full effects of potential treatments on the developing fetus are known. This article reviews the epidemiology, pathology, diagnosis, outcomes, and treatment of NVP and HG.
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