Metformin, Antidiabetic, Anti-Aging and Anti-cancer drug? 9 Stories about Metformin

How does metformin work to lower blood glucose levels in the body?
What is the optimal dosage for people with mild insulin resistance?
Is it better to take metformin with food or without food?
How does metformin improve insulin sensitivity in the body cells?
How can triglycerides contribute to the development of insulin resistance, and what is the mechanism?
How does fat accumulation in non-adipose tissue impair insulin sensitivity, and what is the mechanism?
On what types of cancers is metformin effective, and what is the mechanism?
Is there any evidence that metformin can increase the risk of cancer or aid in cancer development?
Does metformin suppress appetite, and can it cause nausea and vomiting?
Is there any research on the effects of metformin on longevity and aging, and what are the current studies ?