Скачать или смотреть Poor Oral Health Is Associated With Chronic Pain Syndromes

An association between poor oral health, oral microbiota, and pain
identified in New Zealand women with central sensitisation disorders: a prospective clinical study

PMID: 40270934
https://pubmed.ncbi.nlm.nih.gov/40270...

Chronic pain sufferers report lower quality of life, poor sleep, more stress and anxiety, and physical activity limitations, which increase the risk of other chronic diseases. The gut-brain axis may be involved in central sensitisation disorders like migraines, fibromyalgia, IBS, and TMJ. This study examined self-reported oral health, the oral microbiome, and associations with migraines, functional abdominal pain, and body pain in women.

Overall, lower oral health scores were correlated with higher scores on measures of migraine, fibromyalgia, and functional bowel pain. Participants with higher oral health scores had a 5% reduced risk of experiencing frequent migraines and an 8% reduced risk of chronic migraines. Various microbiome changes were observed with varying levels of correlation to the pain syndromes. The authors noted that a higher prevalence and abundance of commensal microbial populations were found in participants with higher OH and lower pain scores.

Possible mechanisms for a link between specific species of the microbiome and pain signaling include changes in pain signaling molecules, growth factors, and neurotransmitters resulting from alterations in microbiota metabolism, as well as an increase in bacterial toxins (LPS). It's thought that oral bacterial metabolites reach distant sites via venous and lymphatic circulation.

Limitations include self-reported findings, a small sample size, a single gender, a lack of a well-defined definition of a healthy oral microbiome, the need for intervention trials, and the use of microbiome samples provided by saliva rather than direct sampling.


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