Treatment of Hyperkaelemia - Prof. Deborah Clegg (El Paso, TX) and Prof. Biff Palmer (Dallas, TX)

Dr. Deborah J. Clegg and Dr. Biff Franklin Palmer present topical treatment approaches for the management of hyperkalemia, based upon their review paper "Hyperkalemia treatment Standard" in Nephrology Dialysis Transplantation - NDT, which has been picked by the journal's Editor-in-Chief Dr. Hans-Joachim Anders and by MARKUS @ HOMe editors as our “NDT's Paper of the Month”

Dr. Deborah J. Clegg is Vice President for Research of Texas Tech University Health Sciences Center El Paso. As a PhD in Nutrition, her clinical and academic work focusses upon obesity, sex hormones, and metabolism, with a specific interest in the interaction between nutrition and physiology.

Dr. Biff F. Palmer is Nephrologist and Professor in the Department of Internal Medicine at UT Southwestern Medical Center. His academic work focusses upon physiology and pathophysiology of human electrolyte regulation.

Together Dr. Clegg and Dr. Palmer have co-authors numerous papers in leading nephrological journals on potassium disorders.

The interview was recorded on April 15st, 2024.

Moderators: Prof. Dr. Andreas Kronbichler (Innsbruck, Austria) and Prof. Dr. Gunnar Heine (Frankfurt, Germany).

Articles discussed:

Hyperkalemia treatment Standard.
Palmer BF, Clegg DJ
Nephrol Dial Transplant 2024
doi: 10.1093/ndt/gfae056

Electrolyte and Acid-Base Disturbances in Patients with Diabetes Mellitus.
Palmer BF, Clegg DJ
N Engl J Med. 2015
doi: 10.1056/NEJMra1503102

Electrolyte Disturbances in Patients with Chronic Alcohol-Use Disorder.
Palmer BF, Clegg DJ
N Engl J Med 2017
doi: 10.1056/NEJMra1704724

A randomized controlled study of finerenone vs. eplerenone in patients with worsening chronic heart failure and diabetes mellitus and/or chronic kidney disease.
Filippatos G, Anker SD, Böhm M, Gheorghiade M, Køber L, Krum H, Maggioni AP, Ponikowski P, Voors AA, Zannad F, Kim SY, Nowack C, Palombo G, Kolkhof P, Kimmeskamp-Kirschbaum N, Pieper A, Pitt B
Eur Heart J 2016
doi: 10.1093/eurheartj/ehw132

A comparison of treating metabolic acidosis in CKD stage 4 hypertensive kidney disease with fruits and vegetables or sodium bicarbonate.
Goraya N, Simoni J, Jo CH, Wesson DE
Clin J Am Soc Nephrol 2013
doi: 10.2215/CJN.02430312

Mechanisms of Metabolic Acidosis-Induced Kidney Injury in Chronic Kidney Disease.
Wesson DE, Buysse JM, Bushinsky DA
J Am Soc Nephrol 2020
doi: 10.1681/ASN.2019070677

KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease.
Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group.
Kidney Int 2024
doi: 10.1016/j.kint.2023.10.018

Noni juice (Morinda citrifolia): hidden potential for hyperkalemia?
Mueller BA, Scott MK, Sowinski KM, Prag KA
Am J Kidney Dis 2000
doi: 10.1016/s0272-6386(00)70342-8

Novel non-steroidal mineralocorticoid receptor antagonists in cardiorenal disease.
Kintscher U, Bakris GL, Kolkhof P
Br J Pharmacol 2022
doi: 10.1111/bph.15747