Скачать или смотреть Scientists at IOCB Prague are developing a new generation of DNA tests for a range of applications

A research group led by Dr. Edward Curtis has developed two new types of catalytic DNA molecules (deoxyribozymes) that can reveal the presence of target molecules through fluorescence or color. Several types of sensors were also developed, one was used to identify small molecule inhibitors of a ribonuclease from SARS-CoV-2 in a high-throughput screen. The results of their research were published as two papers in the leading scientific journal Nucleic Acids Research.

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Read the papers:
Volek, M.; Kurfürst,J. ; Kožíšek, M. ; Srb, P. ; Veverka, V. ; Curtis, E. A. Apollon: a deoxyribozyme that generates a yellow product. Nucleic Acids Res. 2024. gkae490. https://doi.org/10.1093/nar/gkae490

Volek, M.; Kurfürst,J. ; Drexler, M;. Svoboda, M; Srb, P.; Veverka, V.; Curtis, E. A. Aurora: a fluorescent deoxyribozyme for high-throughput screening. Nucleic Acids Res. 2024, gkae467. https://doi.org/10.1093/nar/gkae467