Скачать или смотреть Iscalimab Advancing Research in Autoimmune Diseases and Transplantation

https://www.assaygenie.com/anti-cd40-...

What is Iscalimab?

Iscalimab (CFZ533) is described as an "innovative monoclonal antibody developed by Novartis to target CD40, a pivotal costimulatory protein in immune cell activation."
CD40 is primarily expressed on antigen-presenting cells (APCs) like dendritic cells, macrophages, and B cells.
It interacts with its ligand, CD40L (CD154), found on T cells. This interaction is "essential for initiating and amplifying immune responses, including the activation of T cells, B cell maturation, and the production of pro-inflammatory cytokines."
3. Mechanism of Action:

Iscalimab's primary mechanism involves "selectively block[ing] the interaction between CD40...and its ligand CD40L (CD154), found on activated T cells."
This blockade "interrupts the signaling cascade that leads to T-cell and B-cell activation."
The consequences of this interruption include:
Inhibition of the production of pro-inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ).
Curtailing germinal center formation and plasma cell differentiation, leading to a reduction in autoantibody production.
A key advantage highlighted is Iscalimab's "selective modulation of the immune response," unlike broad immunosuppressants. It "specifically targets the CD40-CD40L pathway without compromising the overall immune cell population," potentially reducing the risk of infections and other side effects.
4. Clinical Applications Under Investigation:

Iscalimab is being investigated for a range of conditions, demonstrating its potential versatility:

Autoimmune Diseases:Sjögren's syndrome: Iscalimab aims to reduce immune activation to alleviate symptoms and slow disease progression.
Lupus nephritis: It may help "preserve kidney function by mitigating the autoimmune attack on renal tissues, offering hope for improved long-term outcomes."
Hidradenitis suppurativa: Mentioned as another autoimmune condition with potential for Iscalimab treatment.
Systemic lupus erythematosus (SLE) and rheumatoid arthritis: Preclinical and clinical studies have shown Iscalimab's ability to "reduce inflammatory markers and attenuate disease progression" in these conditions.
Organ Transplantation:The CD40-CD40L axis is recognized as a "key player in allograft rejection."
By modulating this pathway, Iscalimab aims to "reduce the likelihood of rejection while minimizing the need for traditional immunosuppressants, which often have significant side effects."
"Kidney transplant trials have shown encouraging results, suggesting it could improve graft survival while minimizing the adverse effects of conventional therapies."
Emerging Research:The document mentions ongoing research exploring Iscalimab's role in "conditions like diabetes and myasthenia gravis," highlighting its "versatility as a therapeutic tool."
Chronic Inflammatory Conditions:Iscalimab has shown promise in "chronic inflammatory conditions like Sjögren’s syndrome" (mentioned under both autoimmune and chronic inflammatory).
Certain Cancers:The CD40 pathway's contribution to "tumor-associated inflammation" suggests a potential role for Iscalimab in certain cancers.
5. Advancing Research with Biosimilars:

The document introduces the concept of a biosimilar as "a biologic product highly similar to an original (reference) biologic, with no clinically meaningful differences in terms of safety, purity, and potency."
Assay Genie offers an "Iscalimab (Anti-CD40) Biosimilar Antibody" for research purposes only ("not intended for clinical or patient use").
Benefits of using the Iscalimab Biosimilar for research:"Supports advanced research in immune modulation."
"Provides a cost-effective option for preclinical studies."
"Enables researchers to explore emerging applications of CD40-targeted therapies."