Скачать или смотреть What is PD-1? Ask a Scientist

Jeffrey Weber, M.D., Ph.D., explains what "PD-1" means and its functions. For more, https://www.cancerresearch.org/patien... #AskAScientist #Immunotherapy

PD-1 stands for Programmed Cell Death Protein 1, which is a bit of a misnomer. It is a molecule that exists predominately on the surface of T cells and acts as a brake. Tumor cells are good at evading the immune system and increase expression of PD-L1 on their cell surface, which binds to the PD-1 on the T cell, suppressing the attack. PD-1/PD-L1 checkpoint inhibitors block that interaction and allow the immune system to attack in the way it should.

Jeffrey S. Weber, M.D., Ph.D., is the deputy director of the Perlmutter Cancer Center, NYU Langone Health, and in that capacity, he works with a multidisciplinary team of medical and surgical oncologists, dermatologists, and pathologists to treat patients with melanomas ranging from the most common to the most complex. He serves as co-director of the Melanoma Research Program, overseeing work in experimental therapeutics. An immunotherapy expert, Dr. Weber’s investigations and research findings have brought innovative advances in melanoma treatment from the laboratory to clinical practice. He is a recognized leader in forging collaborative partnerships between basic scientists and clinical and translational investigators to advance cancer care.

Each week in June 2016, as part of Cancer Immunotherapy Month, we published a response to patient questions about cancer immunotherapy clinical trials. This video series is made possible with generous support from Regeneron. #CIM16

Help us raise awareness of the lifesaving potential of immunotherapy for all types of cancer. Let's fuel the next scientific discoveries and breakthrough treatments through learning, engagement, and storytelling during Cancer Immunotherapy Month (CIM). https://www.cancerresearch.org/join-t...

Established in 1953, the Cancer Research Institute (CRI) is a 501(c)(3) nonprofit organization that is dedicated to harnessing our immune system's power to control and potentially cure all cancers. To accomplish this, we rely on donor support and collaborative partnerships to fund and carry out the most innovative clinical and laboratory research around the world, support the next generation of the field's leaders, and serve as the trusted source of information on immunotherapy for cancer patients and their caregivers. Our Mission: Save more lives by fueling the discovery and development of powerful immunotherapies for all types of cancer. https://www.cancerresearch.org