Скачать или смотреть The Effect of an Uncharacterised Mutation in a Tumour Suppressor on Cell Responses, Polina Shevchuk

The protein p53 normally prevents damaged cells from turning into cancers, however, it is mutated in about half of all human cancers causing it to lose its function. Although it is frequently mutated, it is not yet understood how each p53 mutation specifically influences the biology of the cancer cell. One mutation causes significantly worse patient outcomes compared to patients with commonly studied p53 mutations, but it is not yet known why. This project created this singular mutation and showed it causes the cell to respond as if the protein is completely absent from the cell, even though this mutation is the only thing different about the p53. This forms a basis for future studies in understanding exactly what changes happen to the cell when this mutation is present.