Скачать или смотреть What Is Firdapse Amifampridine Used To Treat

What is Firdapse amifampridine used to treat Firdapse is used to treat LambertEaton Myasthenic Syndrome LEMS a rare autoimmune disorderThe disease is caused by autoantibodies against the voltagegated calcium channels located in the neuromuscular junction and results in progressive limb muscle weakness The disease generally affects the extremities especially the legs but occasionally affects the muscles of the mouth throat and eyes The autonomic nervous system can also be affected with symptoms of dry mouth dry skin constipation blurred vision impaired sweating and blood pressure variations The disease can be life threatening when the weakness involves respiratory musclesFirdapse is a broad spectrum potassium channel blocker that works by causing depolarization of the presynaptic membrane This action results in the opening of slow voltagedependent calcium Ca channels and a subsequent influx of Ca which induces the exocytosis of synaptic vesicles containing Acetylcholine ACh to release more ACh into the synaptic cleft Neuromuscular transmission is enhanced and results in improved muscle function