Скачать или смотреть Ion Channels, Sperm Motility, & Fertility - The Chung Lab at Yale School of Medicine

For more information on Jean-Ju Chung or #YaleSchoolOfMedicine, visit: medicine.yale.edu/profile/jean-ju-chung and jeanjuchunglab.org.

The Chung Lab studies membrane receptors, ion channels, and their downstream signaling molecules that regulate sperm motility and fertility in mammals. In particular, they study the primary calcium channel “CatSper” and its accessory subunits. Strong evolutionary pressures on reproduction have endowed sperm with highly evolved and specialized calcium signaling complexes. A long-term goal is to elucidate the unique molecular and structural adaptations in the ion channel complex that mediate successful fertilization in mammalian reproduction. To this end, they use a variety of approaches, including mouse and human genetics, biochemical studies, dynamic optical imaging of live cells, and state-of-the-art super-resolution microscopy. The research has clinical implications for the treatment of human infertility and contraception, and advances our understanding of cell signaling.

0:00 The Chung Lab
0:21 What are they studying?
1:26 How are they studying it?
2:11 Where might this research lead?