Скачать или смотреть Introduction to Bone marrow Innervation ; Route of nerves and Functions of nerves in bone marrow

Bone marrow innervation refers to the presence of nerve fibers in the bone marrow. Here's an introduction to bone marrow innervation:

Types of nerves: Bone marrow contains peripheral nerves, including:
Sympathetic nerves
Parasympathetic nerves
Sensory nerves

Functions: Nerve fibers in the bone marrow:
Regulate hematopoietic stem cell (HSC) mobilization
Promote hematopoietic regeneration after myeloablation (e.g., chemotherapy)
Maintain HSC frequency and function
Regulate circadian rhythms of HSCs

Mechanisms: Nerve fibers interact with bone marrow cells through:
Adrenergic receptors (β2 and β3)
Neurotrophic factors (e.g., nerve growth factor (NGF))
Leptin receptor-expressing (LepR+) stromal cells

Importance: Bone marrow innervation plays a crucial role in:
Hematopoietic regeneration
HSC maintenance
Bone marrow homeostasis

Dysregulation of bone marrow innervation has been implicated in various hematopoietic disorders, highlighting the significance of this complex interaction between nerves and bone marrow cells.

#Bonemarrow