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How to Get Rid of Gas Trouble | What is PPI? What They Are & Side Effects | Raghavendra Hospitals

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Here Dr.Kalyan Thayyur Explains PPI: Proton pump inhibitors (PPIs) are a class of medications that profoundly and persistently reduce stomach acid production by irreversibly inhibiting the stomach's H⁺/K⁺ ATPase proton pump. They are commonly used to treat conditions like acid reflux, ulcers of the stomach and duodenum, and other acid-related disorders. PPIs are among the most potent inhibitors of acid secretion available and are more effective than H₂-receptor antagonists in suppressing gastric acid secretion, reducing it by up to 99%. These medications work by targeting the terminal step in acid production, leading to a significant decrease in stomach acid levels, aiding in the healing of ulcers and reducing indigestion and heartburn symptoms.
PPIs are widely sold and are considered essential medications by the World Health Organization. They are used to treat various conditions such as esophagitis, non-erosive reflux disease, peptic ulcer disease, and as part of Helicobacter pylori eradication therapy. PPIs are generally well-tolerated, with a low incidence of short-term adverse effects, although long-term use may be associated with issues like magnesium or vitamin B12 deficiency, rash, and taste disturbances. It's important to note that while PPIs are effective in reducing stomach acid, adequate stomach acid levels are necessary for the digestion of proteins, vitamin B12, calcium, and other nutrients, highlighting the importance of appropriate use and monitoring when taking these medications.
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