Скачать или смотреть The Deficit Model & Difficult to Treat Depression Featuring Dr. Chris Aiken | Psychofarm Podcast

Dr. Chris Aiken of The Carlat Report joins us to discuss difficult-to-treat depression and underlying causes. We talk about supplements like methylfolate and omega-3, take a deeper look at inflammation and CRP markers, and more!
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In this episode of our psychiatry podcast, we explore depression treatment and the deeper question of when and how to address its underlying causes. Our guest, Dr. Chris Aiken of the carlat report, sheds light on the concept of difficult-to-treat depression, sometimes known as treatment-resistant depression, and why traditional approaches might not always be enough. We discuss the underlying deficit model of mental health, diving into nutritional psychiatry, neuroprotection, and lifestyle interventions that could be key to improving brain health. From supplements like omega-3 and methylfolate to therapies such as light therapy, ECT, and TMS, we look at the full range of options to manage mood disorders like bipolar disorder and major depression.

Throughout the conversation, Dr. Aiken explains how inflammation and markers such as CRP can shape our understanding of root cause factors in mental health. We also examine the role of hormone therapy, including testosterone, in depression treatment, considering the potential benefits and pitfalls. By highlighting psychopharmacology, psychotherapy, and other psychiatric medication approaches, we emphasize the importance of personalized care that focuses on long-term solutions rather than short-term symptom management.

Listeners will come away with practical insights into how psychiatrists can integrate nutritional psychiatry strategies, address possible deficits in brain function, and optimize overall mental health through a combination of evidence-based therapies and lifestyle modifications. We talk about the balance between therapy and medication, how to discern when more specialized interventions are necessary, and why some patients might respond better to certain treatments than others.

Whether you’re interested in understanding why some cases of depression seem unresponsive to conventional medication or how emerging research in supplements and neuroprotection can make a difference, this episode will help you explore new options. Dr. Aiken’s insights emphasize that underlying causes matter—and that with a comprehensive approach involving both established treatments and innovative ideas, real progress is possible even for the most challenging cases of difficult-to-treat depression.

Our discussion also touches on how lifestyle interventions—such as structured exercise, improved sleep hygiene, and mindfulness—can directly impact mental health outcomes. We examine the evidence behind these approaches and discuss how clinicians can tailor them to individual patient needs. By understanding the multifaceted nature of psychiatric care, we hope to broaden your perspective on managing both acute symptoms and the deeper, systemic issues that contribute to chronic mental health struggles. ​