Why gentamicin levels are taken - pharmacokinetics, dosing, monitoring, creatinine clearance

This video goes through the concept of taking gentamicin levels are why they are taken in order to adjust a patient's gentamicin dosing. Also include gentamicin pharmacokinetics, dosing, monitoring, and the Cockroft-Gault formula for creatinine clearance. (Sorry about the choppy audio!)

Time stamps:
0:00 Introduction
1:18 Plasma concentration curve
1:46 First order kinetics
2:45 Post antibiotic effect (POE)
2:59 Once daily dosing vs multi-day dosing
4:16 Concentration dependent killing
4:58 Why once daily is preferred
5:45 Gentamicin in renal impairment
6:51 Initial dose
7:31 Ideal body weight vs actual body weight in obesity
8:24 Deciding on the interval - taking gentamicin levels
10:41 Renal function
11:38 Creatinine
12:27 Cockroft-Gault equation for creatinine clearance


Hospital pharmacists should also refer to their hospital gentamicin dosing guidelines.

Websites used in the video:
IMPACT Body Weight Calculator: https://impact.chp.gov.hk/calculator_...
National Kidney Foundation: https://www.kidney.org/atoz/content/gfr
MDCalc CrCl calculator: https://www.mdcalc.com/creatinine-cle...
IMPACT CrCl calculator: https://impact.chp.gov.hk/calculator_...

I write online tutorials going through Hong Kong registration past papers for pharmacists at www.pharmacyexamquestions.com