SWI/SNF nucleosomal remodeling complex | Epigenetics | GATE/CSIR-NET

The SWI/SNF chromatin remodeling complex is a protein complex that plays a crucial role in modifying chromatin structure to regulate gene expression. "SWI/SNF" stands for Switch/Sucrose Non-Fermentable, referring to the yeast genes where this complex was first identified. This complex uses the energy from ATP hydrolysis to reposition, eject, or alter the structure of nucleosomes to make specific regions of the DNA more or less accessible to transcription factors and other regulatory proteins. This remodeling action can either activate or repress gene transcription.

This video also outlines a possible mechanism by which the SWI/SNF complex functions to remodel chromatin, specifically through nucleosome sliding.