Скачать или смотреть Morphine and Your Body: The Complete Journey from Tablet to Brain | Medical Animation

🔬 MORPHINE: THE COMPLETE BODY JOURNEY | Medical Animation

Ever wondered what actually happens when someone takes morphine? Follow this powerful opioid painkiller's complete journey through the human body - from a single 15mg tablet to its effects on pain, breathing, and brain function.

🎯 WHAT YOU'LL LEARN:

⚕️ PART 1: ABSORPTION (0:00-8:30)
How morphine tablets dissolve and are swallowed
Why the acidic stomach absorbs almost none of it
The critical pH change in the intestines that enables absorption
Why only 20-30% reaches your bloodstream (first-pass metabolism)
How morphine slows its own absorption by reducing gut movement

🧬 PART 2: METABOLISM (8:30-12:45)
The liver's UGT2B7 enzyme and glucuronidation process
M3G formation (inactive metabolite, 50-60%)
M6G formation (MORE POTENT than morphine itself, 10-15%)
Why M6G accumulation in kidney disease causes dangerous toxicity
How 60-70% is destroyed during first-pass through the liver

🩸 PART 3: DISTRIBUTION (12:45-17:20)
Low protein binding (30-35%) allows widespread distribution
Peripheral opioid effects: constipation and urinary retention
Blood-brain barrier penetration despite P-glycoprotein resistance
Why morphine is slower to reach the brain than fentanyl

🧠 PART 4: BRAIN EFFECTS (17:20-26:15)
μ-opioid receptor binding and G-protein signaling
Spinal and supraspinal pain blocking mechanisms
Euphoria and dopamine release in the nucleus accumbens
⚠️ RESPIRATORY DEPRESSION: The main cause of morphine death
Naloxone rescue mechanism (life-saving opioid reversal)
Other CNS effects: pinpoint pupils, sedation, nausea, cough suppression

⚠️ PART 5: TOLERANCE & ADDICTION (26:15-31:40)
How tolerance develops through receptor downregulation
Physical dependence vs. addiction (critical distinction)
Withdrawal symptoms timeline and severity
Addiction neurobiology: 8-12% of users affected
Why constipation never develops tolerance

♻️ PART 6: ELIMINATION (31:40-35:00)
90% excreted by kidneys as M3G and M6G
2-4 hour half-life of morphine
Why kidney disease requires 50-75% dose reduction
Complete elimination timeline: 10-20 hours

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⚠️ CRITICAL SAFETY INFORMATION:
Respiratory depression can be FATAL - dose-dependent risk
M6G accumulates dangerously in kidney disease
Naloxone (Narcan) reverses opioid overdose and saves lives
Tolerance and physical dependence occur in ALL chronic users
Addiction affects 8-12% of prescription opioid users
Constipation occurs in nearly 100% of users and doesn't improve

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📚 MEDICAL ACCURACY:
This animation is based on current pharmacological research and medical literature. All mechanisms, percentages, and timelines reflect established scientific understanding of morphine pharmacokinetics and pharmacodynamics.

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🎓 EDUCATIONAL USE:
Perfect for:
✅ Medical students studying pharmacology
✅ Nursing students learning pain management
✅ Healthcare professionals reviewing opioid pharmacology
✅ Patients prescribed morphine seeking understanding
✅ Anyone interested in how medications work

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⚕️ DISCLAIMER:
This video is for educational purposes only and does not constitute medical advice. Always consult qualified healthcare professionals regarding medication use, pain management, or opioid therapy. Never adjust morphine doses without medical supervision.

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🔗 RELATED TOPICS:
#Morphine #Pharmacology #MedicalAnimation #Opioids #PainManagement #DrugMetabolism #MedicalEducation #Pharmacokinetics #OpioidCrisis #RespiratoryDepression #Naloxone #M6G #FirstPassMetabolism #MuOpioidReceptor