5. Creatine kinase and its isoenzymes in the serum and cerebrospinal fluid of healthy canines

Creatine kinase and its isoenzymes in the serum and cerebrospinal fluid of healthy canines

https://pubmed.ncbi.nlm.nih.gov/37985...

Question 1:
What is the main objective of the study described in the excerpt?
a) To investigate the correlation between CSF CK levels and different neurologic disease categories in canines.
b) To evaluate the efficacy of CSF ultrafiltration in enhancing CK isoenzyme detection in canine cerebrospinal fluid.
c) To establish reference intervals for CK and its isoenzymes in the serum and CSF of healthy dogs.
d) To assess the impact of iatrogenic blood contamination on lactate dehydrogenase and creatine kinase activity in canine cerebrospinal fluid.

Question 2:
Which CK isoenzyme is predominantly found in the CSF of healthy canines, as per the study's findings?
a) CK-BB b) CK-MB c) CK-MM d) All three isoenzymes are found in equal proportions.

Question 3:
What is the potential clinical significance of detecting elevated CK-BB levels in canine CSF?
a) It could indicate acute muscle damage.
b) It may serve as a marker of neurologic disease.
c) It suggests a low level of contamination from penetrating muscle layers during the CSF tap.
d) It reflects normal physiological variation in CK isoenzyme distribution.

Question 4:
Which factor is NOT mentioned as potentially contributing to variations in serum total CK and CK isoenzyme levels?
a) Traumatic venipuncture b) Breed of the dog c) Intramuscular injections d) Exercise