Скачать или смотреть Answers from the Experts: Q&A - April 2025

Do you have questions about cutaneous lymphoma and/or treatments? Our clinical Q&A's are a great way to learn more and empower yourself with knowledge from experts in their field. (For timestamps, click on "...more")

Clinical Panel
Shamir Geller, MD, Memorial Sloan Kettering Cancer Center
Paola Ghione, MD, Memorial Sloan Kettering Cancer Center

Timestamps
2:15 What are the newest treatment options for Sezary syndrome? Anything within the last few years? Will the US government pulling research funds effect newer cutaneous lymphoma research?
3:55 Is it necessary to permanently reduce the dosage of mogamulizumab infusions for Sezary syndrome if one has experienced two episodes of stage 3 moga-associated rash, or should the dosage eventually return to 1 mg. per kilogram of body weight?
5:31 Do skin-directed therapies for early stage CTCL/mycosis fungoides serve any purpose beyond cosmetics and symptom relief? If not, what is on the horizon for early-stage treatments that actually target the disease, and not just the skin.
7:38 How long can the skin be clear before you are considered cured?
8:35 Can we define the difference between a patch and a plaque, and does the presence of plaques in early-stage mycosis fungoides correlate with a poorer prognosis, or not in every circumstance?
12:02 Is CD8+ mycosis fungoides generally considered an indolent variant, and is it believed to respond more favorably to skin-directed therapies? How can we differentiate CD8+ MF from other more aggressive variants?
15:05 What correlations can be made about autoimmune diseases and/or weak immune systems and CTCL. Further, is there a correlation with having autoimmune or weakened immune system and CTCL progression
16:46 I was just diagnosed with MF from a biopsy last week. I have an appointment with a specialist soon. What questions should I ask my doctor? I have a two month old (baby) so I am also worried about how the treatment might impact breastfeeding.
20:07 Has there been any recent update or revision to the 2013 Cutaneous Lymphoma International Prognostic Index (CLIPI) for early-stage mycosis fungoides?
22:58 My brother was diagnosed with Sezary last year. What are the current best course(s) of treatment? If there anything new going through FDA approval process right now?
26:12 Is there a chemo treatment with multiple sessions of injections or chemicals?
29:20 How do we know whether it’s MF, Sezary or something else? I’ve always been told CTCL but nothing further and I've had this since 2009 and most recently now I've just removed a subcutaneous T-cell tumor.
32:07 When the disease has been in remission for almost 4 years with a pause with moga for 2 years and begins to return in the skin with a tiny recurrence in the blood- what is your experience for regaining control?
33:56 What are your thoughts on lacutamab vs moga?
34:55 What is the true percentage of progression in early-stage mycosis fungoides in 2025, and has this risk improved over time through better understanding or treatment approaches?
37:06 What kind of information is available on mental health impacts of this disease and what are doctors doing to support patients in that regard? How would you weigh out the mental health effects of the burden of treatments vs the benefits of treatment for early stage MF?
40:23 Most doctors say patients in early stage disease can expect to live normal life expectancy, is this true?
42:25 How are the stages of lymphomatoid papulosis distinguished?
43:55 Could my regimen of daily exercise, weight training, a healthy diet, and natural skin care meaningfully impact the course of my disease, or is its influence negligible?
45:53 In early-stage disease, the saying goes “you will die with it, not from it”. Does this still apply to those in their younger years as well?
46:56 What is the treatment protocol for the recurrent CBCL?
48:37 Is folliculartropic mycosis fungoides more resistant to skin-directed therapies than classic MF?
49:45 Can mycosis fungoides progress to Sezary syndrome, or are they two different entities? I understand that I think it’s correct to say MF with blood involvement instead of Sezary?
53:15 Is the exposure to sunlight, worth the effort? Is the five minutes well spent?
55:11 For Sezary, I have been recommended to get a bone marrow transplant (BMT) using the Stanford Protocol. Can you discuss alternatives and contrast them. Please describe the protocol at MSK and its advantages / disadvantages.