Immunogenicity causing Antidrug Antibodies: How, Why, Which cells, What and When?

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This is an educational video that provides a high level explanation of what is immunogenicity
Images created based on the following references:
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15) Gorovitz et al. Clin Exp Immunol. 2018 Jun;192(3):348-365. doi: 10.1111/cei.13112

In addition, Saleem Basha Shaik, PhD brought to my attention a paper that explains that both Th1 and Th2 can induce B cell maturity or differentiation.
Below is the published article showed it is both Th1 and Th2.
A L Rothermel 1, K M Gilbert, W O Weigle. Cell Immunol. 1991 Jun;135(1):1-15