Treatment options for Parkinson’s disease psychosis

Stuart Isaacson, MD, FAAN, Parkinson Disease and Movement Disorders Center of Boca Raton, Boca Raton, FL, gives an overview of the current treatment strategies available to treat Parkinson’s disease (PD) psychosis. PD psychosis is a common non-motor symptom of PD characterized by frequent and severe hallucinations or delusions. To treat PD psychosis, it is sometimes necessary to decrease the medications used to control the motor symptoms. Moreover, the treatment is limited by only three available medications (clozapine, quetiapine, pimavanserin) that do not worsen the motor manifestations of PD but have low efficacy. Dr Isaacson also comments on a proof of concept study of a new type of anti-psychotic with the potential to improve treatment. This interview took place during the American Academy of Neurology (AAN) 2021 Annual Meeting.