How Do Orexin Blocking Medications Treat Insomnia? (Dayvigo, Lemborexant, Belsomra, Suvorexant)

This video provides a brief introduction to sleep and insomnia disorder followed by a detailed discussion on orexin and the treatment of insomnia disorder.

Time Stamps
Introduction to the topic: 00:00 to 00:49
Sleep in Psychiatry: 00:50 to 02:41
DSM-5 criteria Insomnia Disorder: 02:42 to 05:04
Types of Insomnia: 05:05 to 06:18
Epidemiology: 06:19 to 07:28
Hypocretin/Orexin: 07:29 to 10:26
Neurobiology of Orexin: 10:27 to 14:11
Why does Orexin blockade work for insomnia: 14:12 to 17:36
Suvorexant and Lemborexant: 17:37 to 20:10
Side Effects of orexin antagonists: 20:11 to 24:16
Pharmacokinetics, metabolism, absorption: 24:17 to 25:22
My take on the medication: 25:23 to 29:40

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Disclaimer: This is not medical advice, and the information is provided for educational purposes only. Please consult your doctor for any specific medical questions.

All content is created for informational purposes only. The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider. If you think you have a medical emergency, call your doctor, go to the emergency department, or call 911. We do not endorse any specific treatment, tests, or procedures. Reliance on this information is solely at your own risk.