Скачать или смотреть Kidneys Part 4 - Glucose reabsorption in the Proximal Tubule. SGLT1 vs 2. Mechanism of Jardiance.

This lecture starts by introducing why glucose is in the renal filtrate and where it starts to get absorbed. It then introduces what SGLT2 proteins are and how they work to reabsorb glucose in the proximal convoluted tubule (PCT). Next it explains why secondary active transport is necessary for glucose to get across the apical membrane of the PCT and why facilitated diffusion would not work. It then discusses the difference between SGLT1 and SGLT2 proteins. It finishes by explaining how Empagliflozin (Jardiance) works in patient with type 2 diabetes to lower blood glucose levels.

0:00 Introduction
3:23 SGLT2
17:50 Why SGLT is Necessary - Glucose Gets Low in Lumen
35:05 Why SGLT is Necessary - GLUT Transport in Both Directions
40:14 Summary of SGLT Necessity
43:53 SGLT1 vs SGLT2
49:05 Summary of Sodium Reabsorption
50:50 Mechanism of Empagliflozin (Jardiance)