Скачать или смотреть How Is 'proof Of Concept' Established In Preclinical Trials? - Trials and Treatments Uncovered

How Is 'proof Of Concept' Established In Preclinical Trials? Have you ever wondered how scientists determine if a new drug or treatment is worth testing in humans? In this informative video, we'll explain the process of establishing proof of concept in preclinical trials. We'll start by defining what preclinical research involves and why this step is essential before human testing begins. You'll learn about the different stages of testing, including laboratory experiments known as in vitro studies, where scientists examine how the drug interacts with its target at the cellular level. We’ll also discuss animal studies that assess how the treatment behaves in a whole organism, focusing on absorption, distribution, metabolism, and excretion—collectively called ADME.

Additionally, we'll cover how researchers evaluate whether the treatment produces the desired effect, known as efficacy, and how they test different doses to find the optimal amount that works without causing harm. For advanced treatments like gene therapies, special considerations such as immune reactions and tissue targeting are also examined. This process helps determine if a treatment should proceed to human trials, which are closely monitored for safety and effectiveness. If a treatment passes this stage, it indicates promising potential, though further testing is always necessary. Whether you're a patient considering participation or simply interested in how new treatments are developed, understanding proof of concept is key to grasping the journey from lab to bedside.

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About Us: Welcome to Trials and Treatments Uncovered, your trusted resource for understanding clinical trials. Our channel focuses on answering your most pressing questions like Should I Join a Clinical Trial? and How do I talk to my doctor about trials?. We discuss topics such as clinical trial expectations, financial support for participation, and emotional considerations throughout the trial process. You’ll also find information on accessing cutting-edge treatments, hearing patient stories, and deciding between standard care and trials, along with details on trial locations and logistics, and long-term follow-ups after trials.