Скачать или смотреть Black Inventors: Donita Brady, PhD. Pharmacologist & Cancer Biologist

Black scientist, Donita Brady, PhD, is a leading cancer biologist. She explores how metals like copper affect cellular signaling, leading to groundbreaking cancer treatments.

For example, her work introduced “metalloallostery.” This concept shows how redox-active metals control kinase activity. It opens new ways to understand and treat cancer by targeting these pathways.

Born near Virginia Beach, Brady completed her undergraduate studies in Chemistry at Radford University in 2003.

Then she earned her PhD in Pharmacology in 2008 from the University of North Carolina at Chapel Hill.

Her doctoral research focused on how cancer cells manipulate normal cellular functions to alter their shape- a crucial aspect of cancer progression.

Next, Brady joined Duke University School of Medicine as a postdoctoral fellow, and later as a senior research associate until 2015.

During this period, she began her pivotal work on the role of copper in cell signaling. Her discovery that kinases require copper for their function was groundbreaking, showing that by inhibiting the copper transporter CTR1, tumor growth could be slowed in mouse models, thus highlighting copper's potential as a therapeutic target in cancer.

In 2015, Brady started her own lab at the Perelman School of Medicine at the University of Pennsylvania, where she holds the position of Professor of Cancer Biology.

Her lab continues to delve into the intersection of kinase signaling and metal homeostasis, particularly focusing on how these interactions can be leveraged in cancer treatment.

One notable contribution from her lab is the understanding that copper not only affects kinase activity but also influences autophagic pathways, which are critical for cancer cell survival.

In 2016, she was recognized as a Pew Scholar in Biomedical Sciences by The Pew Charitable Trusts.

In 2019, Brady received funding from the Stuart Scott Memorial Cancer Research Fund to further her research in pancreatic ductal adenocarcinoma (PDAC), aiming to explore how copper availability influences cancer progression.

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