Скачать или смотреть Drosophila Development 6

The Terminal Signaling System in the fruit fly embryo sets up the head and tail! How?
The Torso Receptor Tyrosine Kinase (RTK) is activated only at the termini (ends) of the embryo by its localized ligand (Trunk). This initiates a signaling cascade (Ras/MAPK) inside the cell.
The final output of the Torso signal is the expression of the tailless (tll) gene, a key transcription factor. Tailless protein is expressed at the poles, where it acts as a repressor.
Tailless represses genes that control central body segmentation, ensuring those segments don't form at the very ends, correctly defining the non-segmented acron (head) and telson (tail).

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