Synthetic Biology: Engineering bacteria with CRISPR - David Bikard

https://www.ibiology.org/bioengineeri...

David Bikard’s talk focuses on engineering bacteria with CRISPR to combat microbial pathogens.  He explains how CRISPR technologies could eliminate antibiotic resistance.

Talk Overview:
Dr. David Bikard’s lab focuses on engineering bacteria with CRISPR to combat microbial pathogens. In this video, he introduces the historical context for using CRISPR in bacteria and then delves into two CRISPR technologies being developed by his lab. Part of his lab is using CRISPR/Cas9 to eliminate antibiotic resistance in bacterial populations. His group is also optimizing a catalytically dead Cas9 (dCas9) to modulate levels of CRISPR-induced transcriptional repression and use it in pooled high throughput screens for gene function.

Speaker Biography:
Dr. David Bikard is the head of the Synthetic Biology Group at the Institut Pasteur in Paris, France. Originally trained in engineering at AgroParisTech, he later received his Masters and PhD from Paris Diderot University for his work with the Institut Pasteur on the intergron bacterial recombination system. He began working with CRISPR during his postdoctoral fellowship with Dr. Luciano Marraffini at Rockefeller University. His work led to him becoming the founder and CSO of the company Eligo Biosciences. In 2014, he returned to the Institut Pasteur as an Investigator in Microbiology.

More information about David Bikard’s work can be found on his lab website:
https://research.pasteur.fr/en/team/s...