Скачать или смотреть EP119: វិធីសាស្រ្ត4 ទម្លាក់ខ្លាញ់ LDL | 4 Tips to Lower Cholesterol LDL

Small dense LDL (sdLDL) and large buoyant LDL (lbLDL) are two subtypes of low-density lipoprotein (LDL) particles, differing in size and density. SdLDL particles are smaller and denser, making them more prone to becoming lodged in artery walls and contributing to atherosclerosis, while lbLDL particles are larger, less dense, and less likely to cause harm.
Here's a more detailed explanation:
Small Dense LDL (sdLDL):
Smaller and denser:
SdLDL particles are physically smaller and more tightly packed than lbLDL particles.
More atherogenic:
This density and smaller size make sdLDL more likely to penetrate the arterial walls and contribute to plaque buildup (atherosclerosis).
Increased risk:
Elevated levels of sdLDL are associated with an increased risk of cardiovascular disease.
Large Buoyant LDL (lbLDL):
Larger and less dense:
These particles are bigger and less tightly packed, making them less likely to penetrate the arterial wall.
Less atherogenic:
lbLDL particles are less likely to contribute to plaque buildup compared to sdLDL.
Not necessarily protective:
While less harmful than sdLDL, lbLDL is still a type of LDL cholesterol and elevated levels can still contribute to overall cardiovascular risk.
Key differences and clinical significance:
Atherogenic potential: SdLDL is considered more atherogenic (plaque-forming) than lbLDL.
Circulation: SdLDL particles are more likely to become trapped in the arterial wall, while lbLDL particles are more easily removed and recycled by the liver.
Clinical measures: Measuring sdLDL levels can be a more accurate indicator of cardiovascular risk than measuring total LDL cholesterol, particularly in individuals with certain metabolic conditions like type 2 diabetes or insulin resistance.
In summary: While both sdLDL and lbLDL contribute to overall LDL cholesterol levels, sdLDL is considered more atherogenic due to its smaller size and higher propensity to contribute to plaque formation in arteries. Understanding the balance between these two LDL subtypes can be important in assessing and managing cardiovascular risk, according to several medical studies.