What is Myelofibrosis?

Myelofibrosis (MF) is scarring in the bone marrow which produces a change in the environment that blood cells live in, causing them to leave the bone marrow and potentially move to other organs, such as the spleen or liver. MF is most often caused by a mutation of the JAK2 gene and sometimes by the CALR or MPL genes. Because of the excess scarring and reduced blood cell production, MF is one of the most serious myeloproliferative neoplasms with a median age of survival at 60 years old and the risk it could turn into acute myeloid leukemia. This rare disease is currently without a large number of treatment options. The Weill Cornell Medicine Richard T. Silver Myeloproliferative Neoplasms Center staff is dedicated to researching and finding new approaches that may work for MF patients. The only known cure at this time is a bone marrow transplant, but not all patients are eligible or able to receive a transplant, therefore increasing the need to discover new treatment options.

Learn more: https://silvermpncenter.weill.cornell...