Скачать или смотреть CH322 Week 1 Lecture 2: Mini-Organic Chemistry Review

This mini-organic chemistry review refreshes key concepts needed for success in medicinal chemistry and pharmacology. The lecture reviews how organic molecules are represented using molecular formulas, condensed structures, skeletal (line) drawings, and 3-D models, emphasizing what structural information each format provides. Students revisit molecular geometry and VSEPR theory to understand why molecules have specific three-dimensional shapes.

The lecture introduces isomers, including structural isomers and stereoisomers, with a focus on chirality and enantiomers. The Cahn–Ingold–Prelog (CIP) priority system is used to assign R/S configurations, and pharmaceutical examples such as thalidomide and ibuprofen illustrate why stereochemistry is critical for drug safety and biological activity.

The review concludes with an overview of common organic functional groups found in drugs, including hydrocarbons, alcohols, amines, carbonyl-containing groups, carboxylic acids, and their derivatives. Emphasis is placed on how structure, functional groups, and 3-D shape influence chemical behavior and biological interactions, laying the groundwork for later discussions of drug binding and pharmacokinetics.