Resin Containing Drug (Part 01) = Ginger & Asafoetida (Source, Preparation Method, Chemicals & Use)

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ASAFOETIDA
Biological source: Asafoetida is an oleo-gum-resin obtained by incision from the living rhizome and root of Ferula foetida Regel. The drug is collected in Iran, Pakistan and Afghanistan.

Collection and preparation. The collection of asafoetida involves removal of the stem and the cutting of successive slices from the vertical rootstock. After each slice is removed, oleo-gum-resin exudes and, when sufficiently hardened, is collected.

Constituents. Asafoetida consists of volatile oil, resin, gum and impurities. The oil has a particularly evil smell and contains sulphur compounds. The flavor is largely due to R-2-butyl-1-propenyl disulphide (a mixture of E and Z isomers). The drug contains no free umbelliferone (distinction from galbanum). Resin contain asaresinotannol and in the form of ester with ferulic acid.

Uses. Asafoetida is employed for the carminative and expectorant properties of the volatile oil fraction. It is an ingredient of certain sauces.

GINGER
Biological source: Ginger (Zingiber) is the scraped or unscraped rhizome of Zingiber officinale (Zingiberaceae). Ginger oleo resin is obtained by percolation method. Extracted with acetone/ethyl ether or ethylene dichloride.

Chemical Constituent
Ginger contains about 1–2% of volatile oil .The rhizomes also contain 5–8% of resinous matter, starch and mucilage. The pungency of ginger is due to gingerol, an oily liquid consistingof homologous phenols. Oil of ginger, consisting of monoterpenes and the sesquiterpene alcohol zingiberol. Zingerone also occurs in the rhizome and, like gingerol, is pungent but possesses in addition a sweet odour.

Uses
Ginger is used as a carminative and stimulant. In motion sickness, ginger is effective in the control of excessive and uncontrolled vomiting occurring in the first trimester of pregnancy and that it might provide a cheap antiemetic adjunct to cancer therapy.

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