Скачать или смотреть [3 + 2] Cycloadditions of Tertiary Amine N-oxides and Silyl Imines with Dr. Sarah Hejnosz

In this Research Spotlight episode hosted by our Editorial Board member Adrián Luguera Ruiz, Dr. Sarah Hejnosz joins us to share her work on cycloadditions with tertiary amine N-oxides and silyl imines.

This episode also has an affiliated problem set available, which is available on our project homepage at synthesis-workshop.com.

Key reference:
Organic Letters 2023, 25 (25), 4638-4643.
https://doi.org/10.1021/acs.orglett.3...

Additional references (in order of appearance):
1) Hung, D. T. WO2009135091A1, 2009; 2) Nickolson, V. J. et al. Journal of Pharmacy and Pharmacology 1981, 33 (1), 760-766; 3) Daly, J. W. et al. Natural Product Reports 2000, 17 (2), 131-135.
1) Roussi, G. et al. Canadian Journal of Chemistry 1985, 63 (3), 725-734. 2) Davoren, J. E. et al. Synlett 2010, 2010 (16), 2490-2492.
1) Chen, Z.; et al. Angew. Chem. Int. Ed. 2022, 61 (47), e202212160; 2) Guram, A. S.; et al. Angew. Chem. Int. Ed.1995, 34 (12), 1348-1350; 3) Chang, Z.et. al. Nature Communications 2021, 12 (1), 4342; 4) Hesp, K. D. et al . Org. Lett. 2012, 14, 2304.
Neal, M. J.; Hejnosz, S. L. et al. J. Org. Chem. 2021, 86 (17), 11502-11518.
Roussi, G. et al. Heterocycles 1992, 34 (2), 293-301.
1) Vrudhula, V. M. et al. US20160016967, 2016; 2) Singh, A. K et al. WO2019089066, 2019; 3) Roy, J. An Introduction to Pharmaceutical Sciences: Production, Chemistry, Techniques and Technology; Elsevier Science, 2011.
1) Kondaparla, S. et al. RSC Advances 2016, 6 (107), 105676-105689; 2) Wixey, J. S.; Ward, B. D. Chemical Communications 2011, 47 (19), 5449-5451.
1) Lee, B. J, et al. Organic Letters 2022, 24 (30), 5513-5518; 2) Wang, C.; et al. Organic Letters 2022, 24 (35), 6455-6459.
1) Karaali, N., et al. Journal of Heterocyclic Chemistry 2020, 57 (4), 1806-1815; 2) Wolfe, J. P. et al. The Journal of Organic Chemistry 2000, 65 (4), 1158-1174.