Disorders of Lipoprotein Metabolism | Hyperlipidemia

I have explained about Disorders of Lipoprotein Metabolism including Hyeprlipoproteinemia and Hypolipoproteinemia
#hyperlipoproteinemia
#hyperlipidemia
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https://drive.google.com/file/d/13t8r...

link for interactive video of the topic :

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Timeline on disorders of lipoprotein metabolism

00:00 Introduction to disorders of lipoprotein metabolism

01:22 Fredrickson classification of hyperlipoproteinemia

04:05 Type 1 Hyperlipoproteinemia
(defect in LPL/Apo CII)

04:33 Type 2 Hyperlipoproteinemia ( 2A defective LDL receptor lead to familial hypercholesterolemia and 2B excess of Apo B lead to familial combined hypercholesterolemia)

05:30 Type 3 Hyperlipoproteinemia
( defect in Apo E : Abnormal ApoE lead to broad beta /disbetalipoprotenemia )

06:15 Type 4 Hyperlipoproteinemia
(Defect in Apo A -V)

06:51 Type 5 Hyperlipoproteinemia

07:17 clinical features due to Hyperlipoproteinemia - xanthoma

08:31 Hypolipoproteinemia

09:01 Abetalipoproteinemia ( bassen kornzweig syndrome)

10:47 Tangier disease

12:35 Revision of Lipoprotein disorders
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The type of hyperlipoproteinemias are given as per Fredrickson’s classification

Inherited defects in lipoprotein metabolism seen in some individuals cause primary hyper and hypolipoproteinemias (Dyslipidemia)

Hyperlipidemia type 1 ( familial hyperchylomicronemia )
Hyperlipidemia type 2 A ( Familial hypercholesterolemia )
Hyperlipidemia type 2 B ( Familial combined [mixed] hyperlipidemia )
Hyperlipidemia type 3 ( Familial dysbetalipoproteinemia / broad beta lipoproteinemia )
Hyperlipidemia type 4 ( Familial hypertriglyceridemia )
Hyperlipidemia type 5 ( Familial mixed hypertriglyceridemia )

You'll learn about their causes and their relation to lipoproteins ( chylomicrons, VLDL, IDL and LDL )

Hypolipoproteinemia :
Abetalipoproteinemia : Defect in Microsomal transfer protein that transfer lipids to chylomicron in intestine and to VLDL in liver leading to defect in Apo B and resulting very low level of Chylomicron , VLDL and so LDL.... resulting in deficiency of fat soluble vitamins and mental and physical retardation . This disease is also called Basen Kornzweig syndrome

in Hypoalphalipoproteinemia - called as Tangier disease where ABC 1 transport protein is defective. Role of ABC 1protein is efflux of cholesterol from peripheral tissue to circulation.. low HDL and low Apo A1 is found. Orange yellow tonsil is seen in tangier disease

Another clinical manifestation
LCAT deficiency : if complete callled Norum disease
Opacification of lens
End stage renal disease
hemolytic ananemia

If LCAT deficiency is partial it is called Fish Eye disease
No end stage renal disease no hemolytic anaemia
only opacification lens is seen.