Скачать или смотреть Small round blue cells histology Feature of Medulloblastoma

medulloblastoma is a classic example of a “small round blue cell tumor”, a term used in pathology to describe highly cellular neoplasms composed of primitive, undifferentiated cells that stain dark blue on H&E due to their dense nuclei and scant cytoplasm 🔬.

🧠 Histologic Features of Medulloblastoma
Small round blue cells:

These cells have hyperchromatic nuclei and minimal cytoplasm, giving them a deep blue appearance on H&E stain.

They are densely packed in sheets or clusters, reflecting the tumor’s high cellularity.

High nuclear-to-cytoplasmic ratio: A hallmark of embryonal tumors like medulloblastoma.

Brisk mitotic activity: Indicates rapid proliferation.

Homer Wright rosettes (in some cases): Tumor cells arranged around a central area of fibrillary material, suggesting neuroblastic differentiation.

Undifferentiated appearance: Reflects the primitive nature of the tumor cells.

🧬 Why It Matters
Medulloblastoma arises in the posterior fossa, typically in the cerebellum, and is classified as a WHO Grade IV embryonal tumor.

The “small round blue cell” pattern helps distinguish it from other pediatric brain tumors and guides further molecular testing and treatment planning.

#Medulloblastoma #Medulla