Скачать или смотреть Cytoplasmic vacuolation In Neutrophils ; Definition, Causes, Characteristics, Disease Association

Cytoplasmic vacuolation in neutrophils refers to the presence of clear, bubble-like spaces within the cytoplasm of neutrophils, often indicating cellular stress, infection, or toxic changes.

Causes & Significance
Severe infections (e.g., sepsis, bacterial infections).

Inflammatory conditions (e.g., burns, trauma).

Toxic granulation—often seen alongside vacuolation in critically ill patients.

Degenerative changes—can occur due to prolonged blood sample storage.

Leukemoid reactions—extreme increases in white blood cell count.

Diagnostic Importance
Peripheral blood smear analysis helps detect vacuolated neutrophils.

Associated with septicemia—early identification can aid in diagnosing severe infections.

Differentiation from leukemia—helps distinguish reactive changes from malignancy.

Management & Interpretation
Address underlying infection or inflammation.

Monitor blood smear findings for disease progression.

Consider additional tests (e.g., leukocyte alkaline phosphatase score) for further evaluation

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