Скачать или смотреть Webinar: NAM Based Prediction of Respiratory Toxicity Using Human and Rat Airway Models

Charles River Laboratories, in partnership with MatTek Life Sciences, is developing a New Approach Methodology (NAM) inhalation toxicology test to reduce reliance on traditional animal research methods, as presented in a poster presented at this year’s Society of Toxicology Annual Meeting. Our presenters will discuss the results of this phase of the project, plans for the next phases of the project, goals for the project, and the changing testing landscape.

This webinar reviews the first phase of the project which evaluated the acute toxicity of a panel of chemicals with known inhalation risk assessment categories in 2D and 3D human airway models, as well as a 3D rat airway epithelial model. This work is part of a larger program which also includes repeat dose responses, aerosol vs liquid applications, and donor differences, with the eventual goal of generating a prediction model for inhalation risk of aerosol chemicals.