Скачать или смотреть Dr. Kristin Hutchins - Facilitating Crystallization and Synthesis of Multi-component Solids

The use of mechanical force to conduct chemical transformations has recently re-emerged as a
green and efficient method for synthesizing metal−organic frameworks, cocrystals, and
conducting organic transformations. Compounds that are not obtainable through traditional,
solution-based techniques have also been successfully prepared using mechanochemistry.
Here, we describe a strategy for crystallizing liquids using a solid component that facilitates
crystallization of the components into a multicomponent solid. The method utilizes
mechanochemistry as a key step in the preparation of the crystals, which are otherwise difficult
or impossible to obtain using standard solution-growth techniques. Spectroscopic
characterization demonstrates a difference in products obtained from mechanochemistry and
failed solution crystallizations. We will also discuss our use of mechanochemical methods for
preparing cocrystals of pharmaceutically-relevant materials.