Two Neurotransmitters May Play Key Role in Meal Initiation

#neurotransmitters #obesity #metabolism

A new study published in the journal Metabolism reveals brain circuits and chemical messengers that contribute to the regulation of meal initiation and food intake. The findings have implications for the development of improved therapies to manage obesity, a worldwide epidemic.
“It’s well known that serotonin, a neurotransmitter in the brain, can suppress food intake. This finding led to the development of drugs that interact with serotonin or its receptors to regulate food consumption and obesity,” said corresponding author Dr. Yong Xu, professor of pediatrics – nutrition and associate director of basic sciences at the USDA/ARS Children’s Nutrition Research Center at Baylor. “However, some of these drugs have unwanted side effects, and they are no longer offered to patients. There is a need to better understand how the brain regulates food intake to improve drug design.”
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