Скачать или смотреть HPR-DS Tablet.Mefenamic acid 500 mg.indication.dosege and administration.sede effects in bd

Indications
Mefenamic Acid is indicated for-
Fever
Toothache
Headache
Migraine
Primary dysmenorrhoea
Menorrhagia
Mild to moderate pain in rheumatoid arthritis and osteoarthritis
Traumatic pain
Low-back pain
Juvenile chronic arthritis in children etc.
Pharmacology
Mefenamic acid contains Mefenamic Acid which is a nonsteroidal agent with demonstrated analgesic, anti-inflammatory and antipyretic activity due to its dual action on prostaglandins. It inhibits the enzymes of prostaglandin synthetase and also antagonizes the actions of prostaglandin at the receptor sites.
Dosage & Administration
Adult:
500 mg dose should be given to adults upto three times (1.5 gm total) per day with meals. The dosage may be reduced to 1 tablet (250 mg) three times daily.
In case of menorrhagia: 500 mg three times daily with meals and from the onset of menses and continued according to the judgement of the physician.
Children:
6 months to 1 year: 5 ml three times/day.
2-4 years: 10 ml three times/day.
5-8 years: 10 ml four times /day.
9-12 years: 15 ml four times/day.
Treatment should not be continued for more than 7 days except on the advice of a physician.
Interaction
Aspirin: As other NSAIDs, concomitant administration of Mefenamic Acid and Aspirin is not generally recommended because of the potential of increased adverse effects.

Warfarin: Mefenamic Acid can inhibit platelet aggregation and may prolong the prothrombin time in patients on warfarin therapy
Contraindications
It is contraindicated in patients with known hypersensitivity to Mefenamic Acid. It should not be used in patients with peptic ulcer, inflammatory bowel diseases, hepatic or renal impairment. It is also contraindicated in patients, whom aspirin and/or other NSAID's have induced symptoms of bronchospasm, skin rashes etc.
Side Effects
The most frequently reported adverse experiences occurring in approximately 1-10% of patients are gastrointestinal: abdominal pain, constipation, diarrhoea, dyspepsia, flatulence, nausea, Gl ulcers, vomiting, dizziness, abnormal renal function, pruritus, rashes.
Pregnancy & Lactation
The safety of Mefenamic acid on reproductive capacity and pregnancy has not been established. Thus, mefenamic acid should be used in women of childbearing potential and during pregnancy only when the potential benefits are expected to outweigh the potential risks. Trace amounts of Mefenamic acid may be present in breast milk and transmitted to the nursing infant. Thus Mefenamic acid should not be taken by the nursing mother because of the effects of this class of drugs on the infant's cardiovascular system.
Precautions & Warnings
It should be administered with caution in allergic diseases especially in asthma. The treatment should be withdrawn in diarrhoea, rashes, cholestatic jaundice, thrombocytopenia, haemolytic anaemia.
Therapeutic Class
Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs NSAIDs
মেফেনামিক অ্যাসিডের মধ্যে মেফেনামিক অ্যাসিড রয়েছে যা প্রোস্টাগ্ল্যান্ডিনগুলির উপর দ্বৈত প্রভাবের কারণে প্রদর্শিত বেদনানাশক, প্রদাহ বিরোধী এবং অ্যান্টিপাইরেটিক কার্যকলাপ সহ একটি ননস্টেরয়েডাল এজেন্ট। এটি প্রোস্টাগ্ল্যান্ডিন সিন্থেটেজের এনজাইমকে বাধা দেয় এবং রিসেপ্টর সাইটগুলিতে প্রোস্টাগ্ল্যান্ডিনের ক্রিয়াকেও বিরোধিতা করে।
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