Скачать или смотреть How science can reverse ageing – and why we’d want to

I believe that ageing is our greatest humanitarian challenge, and that science can help us solve it. Find out more about my book, Ageless: The new science of getting older without getting old at https://ageless.link/

Where to buy

US
Amazon: https://ageless.link/amazon-us
Apple Books: https://ageless.link/apple-books-us
Barnes & Noble: https://ageless.link/barnesandnoble
Books-A-Million: https://ageless.link/booksamillion
Bookshop.org https://ageless.link/bookshop.org
Penguin Random House https://ageless.link/prh
Audiobook on Audible: https://ageless.link/audible-us

UK
Support independent bookshops by ordering from Hive: https://ageless.link/hive
Waterstones: https://ageless.link/waterstones
Amazon: https://ageless.link/amazon-uk
Audiobook on Audible: https://ageless.link/audible-uk

Australia
Amazon: https://ageless.link/amazon-au
Audiobook on Audible: https://ageless.link/audible-au

Other countries
Ageless is also available in other countries around the world—just search for Ageless wherever you get your books, and you should be able to find a copy in English. It’s also in the process of being translated into eleven different languages. You can find out more at https://ageless.link/translations

Some links are affiliate links and I will receive a small payment if you choose to purchase through them. Thanks!


Chapters

00:00 Introduction
00:57 Why ageing is our largest humanitarian challenge
05:24 How science could help
06:07 The hallmarks of ageing
06:22 Senescent cells
08:55 Preventative treatments for ageing
11:04 Where to get Ageless


Sources

Here are some of the sources I used when researching this video:

Calculation of number of deaths caused by ageing based on Human Mortality Database data. You can find a report explaining the calculations, and the code behind it, on GitHub: https://github.com/ajsteele/ageless
Calculations of disease risk with age based on World Health Organization Global Burden of Disease (WHO GBD) statistics. Calculations also available at https://github.com/ajsteele/ageless
Coronavirus mortality with age (technically the age-specific infection fatality rate) was extracted from Figure 2(A) in this paper: O’Driscoll, et al., Nature (2020). https://doi.org/10.1038/s41586-020-29...
The hallmarks of ageing I list are the ones I used in Ageless. They’re based on a paper called the Hallmarks of Aging, published in 2013, which enumerated nine hallmarks. I added two and combined two together, giving one extra hallmark overall. López-Otı́n et al., Cell 153, 1194–1217 (2013). https://doi.org/10.1016/j.cell.2013.0...
The 2011 paper in which scientists removed senescent cells with a ‘suicide gene’: Baker et al., Nature 479, 232–36 (2011) https://doi.org/10.1038/nature10600
The 2015 paper describing the first ‘senolytic’ drug combination, dasatinib plus quercetin: Zhu et al., Aging Cell 14, 644–58 (2015) https://doi.org/10.1111/acel.12344


Thanks

Thanks to Tran Nguyen for her help with this video!


And finally…

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Read my book, Ageless: The new science of getting older without getting old https://ageless.link/