Скачать или смотреть Antidiabetic drugs pharmacology, GLP-1 agonist pharmacology, clinical pharmacology diabetes

💊 Glucagon-like peptide-1 analogs, also known as GLP-1 agonists, are a class of incretin mimetics used primarily in the management of type 2 diabetes mellitus. They mimic the effects of endogenous GLP-1 hormone, which enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety.

➡️ GLP-1 RAs require functioning β-cells and are not effective in type 1 diabetes.
➡️ GLP-1 RAs reduce appetite and slow gastric emptying, leading to significant weight reduction.
➡️ Acute pancreatitis is a serious adverse effect and is a contraindication to continued use.
➡️ Start low, go slow: Titrate dose slowly to minimize GI side effects.
➡️ Avoid coadministration with DPP-4 inhibitors (no added benefit).
➡️ Useful in obese diabetic patients—dual benefit in glycemic control and weight loss.
➡️ Monitor for signs of pancreatitis (abdominal pain, vomiting).
➡️ Counsel patients: Inject on the same day each week for weekly agents.

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Chapters:
0:00 - GLP1 agonists pharmacology
0:24 - GLP1 agonists clinical pharmacology
0:32 - GLP1 agonists and weight loss
0:52 - GLP1 agonists and cardiovascular benefits
1:10 - GLP1 agonists and GI side effects
1:35 - GLP1 agonists and pancreatitis risk
1:55 - GLP1 agonists and renal function
2:18 - GLP1 agonists clinical pharmacology summary

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