Скачать или смотреть MOLECULAR ASPECTS OF AGEING DECODED 🧬 | Advanced Biochemistry Explained in 20 mins | MBBS/NEET/MD

Ever wondered what's really happening inside your cells as you age? In this comprehensive video, Dr. Saif breaks down the fascinating biochemistry of aging – from telomere shortening to the inflammatory processes that drive age-related diseases.

Aging is a progressive decline in physiological function leading to increased susceptibility to disease. But it's NOT just about gray hairs and wrinkles – it's a complex molecular drama playing out in every single cell of your body! 🔬

📚 WHAT YOU'LL LEARN:
✅ Telomeres & the Hayflick Limit – Why your cells stop dividing
✅ Telomerase & Cancer – How cancer cells become immortal
✅ DNA Damage & Repair Mechanisms (BER, NER, BRCA genes)
✅ Epigenetic Alterations – DNA methylation & histone modifications
✅ Mitochondrial Dysfunction & Free Radical Theory
✅ Cellular Senescence & SASP (Inflammaging)
✅ Proteostasis – Link to Alzheimer's & Parkinson's Disease
✅ mTOR & AMPK Pathways – Metformin's anti-aging connection
✅ Advanced Glycation End Products (AGEs) & Diabetes complications

🕐 TIMESTAMPS/CHAPTERS:
00:00 - Introduction: What is Aging?
01:20 - Genetic Factors & Telomeres (TTAGGG Repeats)
02:39 - Telomerase & Cancer Cell Immortality
03:17 - Progeria: Hutchinson-Gilford Syndrome
03:43 - DNA Damage & Repair Mechanisms
05:27 - Epigenetic Alterations (DNA Methylation, HATs, HDACs)
08:22 - Mitochondrial Dysfunction & ROS
09:55 - Cellular Senescence & SASP
11:37 - Proteostasis & Protein Aggregates
13:27 - mTOR & AMPK Pathways
15:21 - Inflammaging Theory
16:22 - Glycation & AGEs (Advanced Glycation End Products)
17:40 - Summary & Key Takeaways

🔑 KEY TERMS COVERED:
Telomere shortening | Hayflick limit | Replicative senescence | DNA polymerase | Telomerase reverse transcriptase | Progeria | Base excision repair | Nucleotide excision repair | Double-strand break repair | BRCA1 BRCA2 | Epigenetic drift | DNA methylation | Histone acetylation | HATs HDACs | Sirtuins | Mitochondrial ROS | Free radical theory of aging | Mitophagy | Cellular senescence | SASP | Inflammaging | Proteostasis | Chaperones HSP70 HSP90 | Ubiquitin proteasome system | Autophagy | Amyloid beta | Tau protein | Alpha-synuclein | mTOR pathway | AMPK pathway | Rapamycin | Metformin | AGEs | RAGE receptors | Maillard reaction

📖 This video is perfect for:
• Medical students preparing for biochemistry exams
• MBBS/MD students studying gerontology
• Healthcare professionals interested in aging research
• Anyone curious about the science of longevity

🎓 Understanding these molecular mechanisms can help develop therapies to promote healthy aging and combat age-related diseases. The fight against aging isn't about finding a fountain of youth – it's about understanding each molecular player and learning how to restore harmony.

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