Скачать или смотреть Diagnostic criteria and a prognostic score for Hep B-related acute-on-chronic liver failure

To cite: Wu T, Li J, Shao L on behalf of the Chinese Group on the Study of Severe Hepatitis B (COSSH), et al. Gut 2018;67:2181-2191.

Read the full article here: http://dx.doi.org/10.1136/gutjnl-2017...

Objective: The definition of acute-on-chronic liver failure (ACLF) based on cirrhosis, irrespective of aetiology, remains controversial. This study aimed to clarify the clinicopathological characteristics of patients with hepatitis B virus-related ACLF (HBV-ACLF) in a prospective study and develop new diagnostic criteria and a prognostic score for such patients.

Conclusions: Regardless of the presence of cirrhosis, patients with CHB, TB ≥12 mg/dL and INR ≥1.5 should be diagnosed with ACLF. The new criteria diagnosed nearly 20% more patients with an HBV aetiology with ACLF, thus increasing their opportunity to receive timely intensive management.