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In this video, I discuss the essential skills needed to thrive in bioinformatics amidst the rise of artificial intelligence. I emphasize five foundational skills: understanding data formats, mastering statistical methods, validating biological logic, conducting thorough code reviews, and implementing rigorous testing strategies. Notably, a report shows that 80% of AI-generated bioinformatics code requires human review, and even advanced models like ChatGPT4 achieve only 50% accuracy on complex tasks. I encourage you to trust but verify AI outputs and to build a solid foundation in programming and biological principles. Join the reproducible research movement and connect with the community to enhance your expertise in this evolving field. AI in Bioinformatics.