Скачать или смотреть How Anti Nausea Meds Work

An extensive overview of the neurophysiology of nausea and vomiting, explaining that the vomiting reflex is controlled by the medulla's vomiting center, which gathers input from areas like the chemoreceptor trigger zone, the vestibular system, and the cerebral cortex. The document then details the profiles of several antiemetic drugs, including their classification, mechanism of action, primary and alternative uses, and significant side effects. Specific drugs examined are Ondansetron, Metoclopramide, Dexamethasone, Scopolamine, and Lorazepam, each targeting different receptors (e.g., serotonin, dopamine, acetylcholine) to disrupt the vomiting pathways. Finally, the text addresses the risk of extrapyramidal symptoms (EPS) associated with dopamine blockers like Metoclopramide and explains the use of Diphenhydramine to manage these acute reactions. The information concludes with clinical pearls to guide appropriate antiemetic selection based on the cause of nausea and the patient's risk factors.