BIH Lecture: Lijian Hui

Lecture 29: "Cell Identity Conversion: Liver Regeneration and Cell Therapy"

In the BIH Lecture on March 31, 2023, Lijian Hui (Chinese Academy of Sciences, Shanghai) talked about the aspirations of his lab to one day transplant human hepatocytes to cure liver or genetic diseases. Professor Hui studies molecular pathology of liver diseases, with the focus on cell identity conversion in liver regeneration and tumorigenesis. The Hui Lab demonstrated the conversion from fibroblasts into hepatocytes in vitro, thereby providing one of the first evidence of transdifferentiation in mammalian cells. His team is among the first to report cell identity conversion in liver injury and repair. Based on these findings, his team generates functional hepatocytes, hiHep and ProliHH, and corresponding innovative therapies like bioartificial liver devices and encapsulated liver organoids, are now being tested in clinics.

The lecture was moderated by Ludovic Vallier (BCRT) and supported by the German Stem Cell Network.

The lecture was held in hybrid format and on-site at the BIH Center for Regenerative Therapies (BCRT): https://www.bihealth.org/en/research/...

Moderator: Ludovic Vallier (W3 Einstein-Professor for Stem Cells in Regenerative Therapy): https://www.bihealth.org/en/notices/l...

Further information on this BIH Lecture: https://www.bihealth.org/en/notices/b...

About the Speaker: http://english.cemcs.cas.cn/faculty/p...

Further information on the BIH Lecture Series "Frontiers in Translational Medicine - Scientific and Structural Challenges": https://www.bihealth.org/en/news/even...

supported by the German Stem Cell Network (GSSCN): https://gscn.org/conferences-events/g...