Tumour Lysis Syndrome

Tumour Lysis syndrome is an oncological emergency whereby the lysis (or breakdown) of vast numbers of cells leads to the release of their contents, which can have catastrophic consequences for the function of the kidneys, heart and central nervous system.

This video describes the pathophysiology of TLS, risk factors, clinical definition and diagnosis, prevention and management.

References
Larson, R., & Piu, C. (2016). Tumor lysis syndrome: Definition, pathogenesis, clinical manifestations, etiology and risk factors. In D. Savarese (Ed.), UpToDate. Retrieved December 10, 2017, from https://www.uptodate.com/contents/tum...
Larson, R., & Piu, C. (2016). Tumor lysis syndrome: Prevention and treatment. In D. Savarese (Ed.), UpToDate. Retrieved December 10, 2017, from https://www.uptodate.com/contents/tum...