Скачать или смотреть Neurobiology of the Body-Clock in Health and Disease - Part 1

Andras David Nagy, MD, PhD
Associate Professor, University of Pécs Medical School, Department of Anatomy, Pécs, Hungary

Chronobiology is a relatively small scientific discipline established in the 1950's dealing with biological timing mechanisms. With the discovery of the so called "clock genes", it reached a broad scientific acceptance in the late 1990's. Virtually all cells in our body run a molecular clock mechanism which orchestrates metabolic and signaling processes in a daily rhythmic manner. Artificial disruption of these near 24 hour periodicities results in metabolic imbalance which is linked to a worse prognosis in cancer development and is associated with a higher incidence of obesity and its related cardio-vascular morbidities. Resynchronisation of the body clock is an already established therapeutic strategy for several types of affective disorders. This workshop summarises recent knowledge on: (1) molecular evidences from the post-genomic era, (2) experimental models for disease development and therapy, (3) translational science for clinical strategies, and (4) the epidemiological impact of running a healthy clock.