Difference between DEXAMPHETAMINE & METHYLPHENIDATE in ADHD | ADDERALL | RITALIN | DR REGE EXPLAINS

DEXAMPHETAMINE and METHYLPHENIDATE are medications used to treat Attention-deficit Hyperactivity Disorder (ADHD).
Dr Rege, Consultant Psychiatrist explains the differences between the two.
#adhd #adderall #ritalin #vyvanse #dexamphetamine #methylphenidate #amfetamine

Methylphenidate (MPH)
Mechanism of Action:
Methylphenidate (MPH) non-competitively blocks the reuptake of dopamine and noradrenaline into the terminal by blocking dopamine transporter (DAT) and noradrenaline transporter (NAT), increasing levels of dopamine and noradrenaline in the synaptic cleft.


Amphetamine has a d-isomer and an l-isomer.
The d-isomer is the active isomer.
Mechanisms of action :
1. Competitive inhibitor at DAT competing with dopamine and noradrenaline at NAT.
2. Competitive inhibitor of VMAT
3. Reversal of DAT.

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Correction:

6:20 LDX as a prodrug has a biological mechanism of drug delivery that uses enzymatic hydrolysis to convert the therapeutically inactive molecule to the active drug, d-amphetamine. Conversion of LDX to the active metabolite d-amphetamine occurs primarily in the blood through enzymatic cleavage after active absorption of LDX from the GI lumen.