Скачать или смотреть Endocrinology | Pancreas: Insulin Function

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Ninja Nerds!
In this endocrine physiology lecture, Professor Zach Murphy presents a comprehensive breakdown of insulin, a key anabolic hormone secreted by the beta cells of the pancreatic islets. This lecture emphasizes insulin’s critical role in glucose regulation, energy storage, and cellular uptake of nutrients, particularly during the fed state.

We begin by reviewing the stimuli for insulin secretion, primarily elevated blood glucose, along with potentiating signals from incretins such as GLP-1 and GIP, and hormones like CCK and secretin. From there, the lecture explores insulin’s effects on key target tissues—liver, skeletal muscle, and adipose tissue—including the promotion of glycogenesis, lipogenesis, and protein synthesis, while inhibiting gluconeogenesis, glycogenolysis, and lipolysis.

You’ll also learn about the insulin receptor, a tyrosine kinase, and how its activation triggers intracellular signaling cascades that mediate glucose uptake through GLUT4 translocation, enzyme regulation, and gene expression. The lecture also ties in pathophysiologic relevance, including the differences between type 1 and type 2 diabetes mellitus, insulin resistance, and hyperinsulinemia.

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