Скачать или смотреть A Classical Model of DNA Stability (Notes included)

This notes presents a mathematical model of DNA stability, focusing on the interplay between hydrogen bonding and helical structure. Hydrogen bonds between base pairs (A-T and G-C) contribute to stability, with G-C bonds being stronger due to three hydrogen bonds versus two in A-T bonds. The model incorporates equilibrium constants reflecting the strength of these bonds. Additionally, the model accounts for torsional strain arising from deviations in the DNA helix's natural twist, quantified by an energy term related to helical stiffness. Combining these energetic contributions allows for the calculation of the total free energy of the DNA molecule, providing insight into its overall stability. Environmental factors, like temperature and ionic strength, can further modulate stability.



Notes: https://github.com/PodcastLearn/Class...